In the isolated, desolate, decrepit village of Dunwich, Massachusetts, Wilbur Whateley is the hideous son of Lavinia Whateley, a deformed and unstable albino mother, and an unknown father (alluded to in passing by mad Old Whateley, as Yog-Sothoth). Strange events surround his birth and precocious development. Wilbur matures at an abnormal rate, reaching manhood within a decade. Locals shun him and his family, and animals fear and despise him due to an unnatural, inhuman odor emanating from his body. All the while, his grandfather, a sorcerer, indoctrinates him into certain dark rituals and the study of witchcraft. Various locals grow suspicious after Old Whateley buys more and more cattle, yet the number of his herd never increases, and the cattle in his field become mysteriously afflicted with severe open wounds.
Wilbur and his grandfather have sequestered an unseen presence at their farmhouse; this being is connected somehow to Yog-Sothoth. Year by year, this unseen entity grows to monstrous proportions, requiring the two men to make frequent modifications to their residence. People begin to notice a trend of cattle mysteriously disappearing. Wilbur's grandfather dies, and his mother disappears soon. The colossal entity eventually occupies the whole interior of the farmhouse.